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Selank and BDNF

Scientific study based on animal test subjects has determined that there has been a link between Selank and brain-derived neurotropic factor, also known as BDNF. This particular protein, which is encoded by the BDNF gene, is determined to be part of the neruotrophin family of growth factors, which in turn are linked to the canonical Nerve Growth Factor. Studies that have been built around the hippocampus of rats (that is, the part of the brain responsible for processing spatial navigation and consolidating information from short-term memory to long-term memory) have shown that the presence of the peptide can cause a rapid boost of the expression of the protein. This increased boost can theoretically improve the following processes:

• Survival support of existing neurons
• Growth and differentiation of new neurons
• Growth and differentiation of new synapses

Ultimately, an increase in BDNF could lead to a more stabilized means of processing and retaining long-term memory. As such, it has been thought that the presence of Selank could be an effective aid in the ongoing study of certain memory impairment-related conditions, such as Alzheimer’s disease.

Properties of Selank

Typically, Selank is presented in the form of lyophilized powder; that is, a powder that has been freeze-dried. In terms of solubility, the peptide has been determined to be soluble in either water or in 1% acetic acid.

Because it is delivered to laboratories or research centers in a lyophilized state, it is thought that the peptide should be stored desiccated at a temperature below -18 degrees Celsius. Upon the peptide’s reconsititution, re-storage depends on the interval of time it will be out of storage. If it is going to be re-stored within a time interval of 2 to 21 days, it should be stored at 4 degrees Celsius. It if is going to be re-stored for a length of time beyond the 21 day time frame, it should be stored at below -18 degrees Celsius.

In terms of Selank administration, it should be noted that the peptide cannot be introduced orally. The reason for this is because it is a peptide that would be hydrolyzed and in essence broken down to its base amino acids within the animal test subject’s gut.

In the latter form of administration, it is important that Selank is dissolved into a soluble substance that will not interfere with the peptide’s overarching functionality. It has been shown that the peptide, when administered in this manner, is quickly absorbed by the animal test subject’s nasal mucosa, and ultimately the blood plasma, where it is carried throughout the test subject’s vascularized organs.

Selank and Anhedonia

Although there have been no major negative side effects associated with Selank, there has been some ongoing scientific study on animal test subjects that has set out to determine whether or not the absence of the peptide could be linked to anhedonia after the testing period. Anhedonia essentially is defined as the reduced ability to experience pleasure, and it has been thought that because Selank has been linked to improving various forms of cognitive thought, it has been theorized that the animal test subject can experience a lack of motivation once the peptide wanes. With this being said, the results of this theory are currently inconclusive, as there is currently a lack of long-term data to support this hypothesis one way or the other.

Purchasing a Peptide Such as Selank

There are in essence three basic metrics that should always be at the forefront of the purchase of any peptide such as Selank.

The first metric is the assurance of the peptide’s purity level; specifically, the higher the purity in this case, the better the peptide. A lower purity percentage peptide may cause an increase in research variance, which could end up compromising the overarching integrity of the research data.

Secondly, it is always a good idea to ensure the proper amount of peptide that is needed for the duration of the research. This does require the person conducting the study on animal test subjects to have a solid bead on what goals are being set out to meet. Anything else ordered that goes beyond this set parameter would be considered a waste of peptide.

Finally, it is always important to double check with the supplier to make sure that the proper research materials with the peptide are being delivered. This simple step will go a long way in eliminating the guesswork about a peptide’s administration or storage properties once it has been received.

Click here to read Selank – Part 1

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The peptide Selank is considered to be a heptapeptide.  What this means is, it is a peptide chain that is consisting of seven amino acids.  It contains a molecular mass of 751.9, a sequence of Thr-Lys-Pro-Arg-Pro-Gly-Pro, and it has a molecular formula of C₃₃H₅₇N₁₁O₉.

Selank at a Glance

According to scientific study that has been conducted on animal test subjects, it has been shown that the way in which Selank operates allows it to have the capacity to boost the secretion of serotonin.  This is the neurotransmitter that is tied to several elements that are linked the regulation of the following functions:

• Mood
• Sleep
• Appetite

The presence of the peptide has been shown to produce an increase of serotonin’s release, which in turn means that it boosts the efficiency in the way in which serotonin operates.  This ultimately means that the animal test subject can ultimately experience a more efficient means of achieving homeostasis in the functions that are linked to serotonin.

In addition to working in conjunction with serotonin, it has been shown through scientific study on animal test subjects that the Selank has the capacity to facilitate the concentration of monoamine neurotransmitters.  These are neuromodulators and neurotransmitters that posses one amino group that is connected to an aromatic ring through a two-carbon chain.  Monoamine neurotransmitters work in a similar fashion to serotonin in the sense that they play a vital role in the regulation of specific cognitive processes within an animal test subject, such as emotions, arousal, and certain types of memory.  It has been shown that the presence of Selank can provide a boost in the regulatory functions of the monoamine neurotransmitters, which could then allow the animal test subject to experience various cognitive processes on a much easier, more efficient basis.

It has also been determined through scientific study based on animal test subjects that Selank has the capacity to modulate the expression of a secretion known as interleukin 6.  This particular secretion, which is expressed by white blood cells in an animal test subject, has the capacity to act as either a pro-inflammatory cytokine or an anti-inflammatory myokine, depending on the situation.  Interleuken 6 has been shown to play a vital role in the stimulation of the immune response in the midst of infections or in the aftermath of trauma, especially during instances of tissue damage leading up to infection.  Because Selank has the ability to modulate interleukin 6’s expression, it is determined that it can produce a more efficient means of fighting off infection and speed up the immune process.

Selank and Perceived Benefits

Because of the way in which Selank has been shown to function, scientific study based on animal test subjects has determined that the peptide’s presence could make it instrumental in various treatments.

Because of its relationship with serotonin and monoamine neurotransmitters, it has been determined that the peptide could have the capacity to play a key role in fending off various emotional anxiety disorders, such as depression.  Furthermore, it has been determined that the peptide’s presence could yield a stabilization of mood, which could create a more consistent sense of well-being.  Plus, it has been theorized that Selank’s relationship to cognitive thought could produce an increase in various functions that correlate to cognition.  Some of these functions include an increase in mental clarity, a boost in sensory attention, and a boost of learning and various memory processes.

It has also been perceived that Selank could potentially provide treatment and aid from various sleeping disorders.  The reason for this theory is due to the way in which the presence of the peptide has been shown to boost the overall functionality of neurotransmitters.

It should also be noted that while these scientific studies on animal test subjects have yielded various theoretical benefits, they have also yielded the notion that the peptide causes very little negative side effects.  The ones that have been caused has been mild in nature, such as fatigue.

Click here to read Selank – Part 2

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