Month: April 2013

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Bremelanotide is a compound that is currently under investigation for its potential uses in managing reperfusion injury, female sexual dysfunction or hemorrhagic shock. The chemical may also see success in managing modulate inflammation or limiting the effects of ischemia.

Study – Potential Use Erectile Dysfunction

One study has explored the potential use of bremelanotide as a replacement for natural peptide melanocyte stimulating hormones for the sake of treating erectile dysfunction.

• The goal of this study was to determine if the effects of bremelanotide stimulating sexual desire that was shown in male rats could be replicated in the brains of female rats. To do this, hormone primed female rats in a control group and a test group that were treated with bremelanotide and known to have consummatory sexual disorders was introduced to a group of male rats and the reactions were measured.

• Heart racing, hops and darts, pacing and customary sexual behaviors were assessed while the brain was stimulated. The stimulation of specific molecular markers within the brain was examined to determine arousal in the female subjects.

• Results indicated that the females saw an increase in sexual behavior when bremelanotide was applied to the limbic and hypothalamic regions of their brains. It is suggested that this was because the chemical that stimulated the mPOA terminals, leading to activated dopamine in the brain.

Additional study is necessary to determine the extent of the effects bremelanotide has on the brain and natural stimulating chemicals. Research companies buy bremelanodtide in our online store located right here at www.extremepeptides.com.

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Igf-1 lr3 is the chemical name for insulin like growth factor 1 long r3. In research studies it was also found that this chemical is responsible for hyperplasia that causes the muscles cells to split and form new tissue. Experiments with lab rats revealed that increasing this natural peptide will increase muscles cell density.

The artificial version of igf-1 lr3 is designed to promote protein synthesis and nitrogen retention in a similar fashion to the natural chemical found in animal cells. This will help to make the muscles grow, not by adding additional bulk to the tissue, but by encouraging new tissue to grow to create a larger amount of muscle cells.

Applying this chemical to an animal’s body has also been found to increase the body’s ability to burn fat. Some suspect that this also increases neuro function in animals, but studies are currently inconclusive.

Specific Chemical Makeup

Igf-1 lr3 is made up of 70 amino acids which help it to be identified as growth factors that will impact the skeletal muscle and peripheral tissues like those released naturally from the animal’s liver.

• Chemical versions of igf-1 lr3 are not sterile and therefore not considered appropriate for injections. It is also not considered appropriate for ingestion.

• This chemical acts as a neruoprmotor and neruoprotector that may have an impact on the memory, reflexes and learning ability of the animal subjects regularly exposed to this peptide during research.

• The chemical is designed to increase the production of connective tissue while ensuring the proper bone density in the animal’s body. However, ongoing research is being used to determine if an animal reacts to the synthesized version of this chemical the way it does the natural peptide produced by the liver.

• This chemical should not be confused with lr3IGF-1. This is an 83 amino acid that is designed to mimic the effects of the human igf-1 rather than that that is present in smaller animals. Lr3IGF-1 will substitute Arg for the Glu in its position, and help to manage the extension of the peptide in the N-terminus in the body.

Research is ongoing to determine the specific reactions to natural igf-1 and its impact on the anabolic activities in an animal’s body. Research is also hoping to indicate how an animal’s body relates to the synthesized versions of this chemical as opposed to that which is naturally produced by the liver.

Igf-1 can be administered to animal subjects on its own because the structure and size mimics that of insulin, making it easy for the animal’s body to address the peptide as though it were a natural chemical. However, studies have found that igf-1 lr3 is considerably more effective in building new muscle tissue and burning fat. Ongoing studies comparing the two are largely focusing on providing more information on how these peptides affect diseases and potential side effects.

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(Click here to read our disclaimer) Modified grf 1-29 was originally sold under the name tetrasubstitued grf (1-29). Some research facilities may still be using this name for the sake of consistency with previous research which can cause some confusion for buyers. Both of these identifiers are used to refer to a 29 amino acid peptide. This is a modified version of this functional fragment that is typically abbreviated to growth releasing factor or grf 1-29. It is also marketed under the name sermorelin. Mod grf is designed to replace the 2nd, 8th, 15h and 27th amino acids in this peptide sequence. These amino acids in the grf 1-29 sequence will yield a modified grf (1-29) sequence, with an approximate half-life of 30 minutes. This peptide is applied during animal research to increase the presence of hormones and the animal’s production of these hormones by binding to the hormone receptors. Want to buy buy modified grf 1-29 online? Click here to buy modified grf 1-29 in our store!

Specific Origins of GRF 1-29

The initial 29 amino acids were discovered to be just as potent as the total 44 amino acid structure that animals naturally produce.

• Subsequent production of this fragment came to be known as grf 1-29 but the rapid metabolic clearance of grf 1-29 was synthesized in order to enhance the biological activity of the animal while rapidly allowing for metabolic clearance.

• Grf 1-29 was designed to substitute the amino acids in the natural peptide structure with those that would be more resistant to the inevitable enzymatic cleavage.

• Additional substitution has allowed grf 1-29 to be altered to crease a variety of half-life conditions that can be customized to address the needs of the specific animal in which the synthesized amino acid is being applied.

Grf 1-29 was first mentioned in the use of tetrasubtitued research during a 2005 study which was designed to better understand the structures of this peptide. The specific notations referred to the structure of grf 1-29 when the 2nd, 8th, 15th and 27th amino acids had been replaced with alternative structures. In 2008, DatBtrue created the official term modified grf 1-29 to refer to tetrasubstitued grf in articles that would be published for the public. Since this time, this has become the standard reference on both public and private nomenclature. Modified grf (1-29) is designed to act as a synthetic modification of factors with substitutions of gln, d-ala, ala and leu. These allow the peptide an increased stability, which encourages additional chemical synthesis. This peptide is soluble in water or in 1 percent acetic acid for intravenous applications on animal test subjects. The increased stability of the synthetic peptide allows for storage at 2-8 degrees Celsius but those that plan to use this peptide for long term research applications should desiccate the peptide and store it at -20 degrees Celsius.

Sources

http://en.wikipedia.org/wiki/Modified_grf

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