May 2013 – Page 4 – Extreme Peptides

Anastrozole – Chemical Mechanisms And Study

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Anastrozole is commonly produced under the name Arimidex. This chemical is not naturally occurring and is currently not available outside of laboratory settings. Scientists are currently investigating this chemical’s impact on estrogen receptors or conversion mechanisms– both in an artificial and natural state.

Anastrozole was designed to act as an aromatase-inhibiting chemical that may have applications toward metastasis. Potential use in combatting the effects of hyperplasia is currently being studied, as is the reactions of anastrozole when interacting with the synthesis of estrogen.

The patent on this chemical expired in 2010 which has opened the door for additional testing and research on these effects.

Chemical Mechanisms

Anastrozole is prepared in laboratory environments by subjecting mesitylene to a radical brominisation process.

Anastrozole is prepared by substituting two benzylic for cyanide, treating the chemical with potassium cyanide using a phase transfer condition.

The methylation of this chemical with sodium hydridie and methyl iodide creates an acidic compound that includes several methyl groups and hydrogen atoms.

Treating bromine along with benzyl peroxide will create a corresponding benzyl bromide reaction that creates the base for the aromatase inhibitor.

Additional compounds can be created using a similar process. This allows manufacturers to create variations on the compound to increase or decrease the strength of the chemical as necessary. Varying compositions of anastrozole can be used in laboratory settings to act as carriers or diluents based on the nature of the study.

Study

Studies are ongoing to determine the usefulness of using anastrozole for medical application in the future.

Ongoing studies are in progress to assist in determining the inhibiting properties of anastrozole as well as the process of compounding these chemicals to create a variation of strengths of this chemical.

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Extreme Peptide launches custom protein expression!

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Extreme Peptide has been meeting the needs of clients since 2011. The foundation of our company has been the ability to offer a high quality product, to exact specifications and in a manner that ensures the highest accuracy for your research. We have compiled a catalog of many standard research proteins and peptides; and we’re adding more every week. All products are available from our website. Start with the appropriate category (proteins, epidermal growth factors, insulin growth factors, etc.), and search from there.

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A partnership with Extreme Peptide ensures that you have a professional support team capable of understanding your requirements and delivering custom solutions on specification, on time, and on budget. If you are interested in our protein expression or peptide synthesis services please contact us so that we can discuss your specific needs. We appreciate your interest in our products and services, and we look forward to a long and successful relationship.

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