Finasteride Part 2

finasteride
Click the image above to view Finasteride in our store

Lipophilic Properties of Finasteride

According to scientific study based on animal test subjects, it has been determined that Finasteride is lipophilic in nature. What this means is, it has the ability to dissolve in the following substances:

  • Fats
  • Oils
  • Lipids
  • Other non-polar solvents

A lipophilic substance such as Finasteride has the capacity to interact within themselves and via other substances through what is known as the London dispersion force, which is a weak intermolecular force that rises from quantum-induced instantaneous polarization multipoles in molecules, and thus can act between molecules without permanent multipole moments.  Furthermore, a lipopholic substance contains little to no ability to form hydrogen bonds.  These properties make the substance water insoluble, which is somewhat intriguing since it is soluble in so many other solvents.

Side Effects of Finasteride

According to scientific study that has been conducted on animal test subjects, it has been determined that the potential for adverse effects stemming from the presence of the catalog chemical is relatively rare. With that being said, it has been theorized that the group of 5α-reductase inhibitors such as Finasteride could be linked to an uptick in the risk of developing high-grade prostate cancer. The reason for this theory stems from the catalog chemical’s ability to reduce the volume of the prostate as a means to slow the condition of hyperplasia. It is thought that this correlation could potentially lower the presence of Prostate-Specific Antigen, also known as PSA, which could in turn make it more difficult to detect the development of prostate cancer. With that being said, it must be emphasized that this does not mean that the presence of Finasteride could be considered a cancer-causing agent.

Further theories regarding the presence of Finasteride and a link to various forms of sexual dysfunction in male animal test subjects have also been theorized as a result of the catalog chemical’s relationship with the prostate gland. However, there has been no concrete evidence derived from scientific study on animal test subjects that would make this theory one-hundred percent conclusive.

Detailed Study of Finasteride’s Action

Scientific study based on animal test subjects has shown that a single dose of Finasteride when given to the subject orally produces a rapid drop in serum DHT concentration. It has been shown that the apex of this drop occurs approximately 8 hours after the initial dosage. DHT’s suppression is further maintained during the ensuing 24 hours after the initial introduction of the catalog chemical, as well as continued catalog chemical administration.

These studies have further indicated that when the catalog chemical is introduced on a daily basis over a 4-year interval, it has been shown that it can reduce serum DHT concentration by an estimated 70%. It was also determined that the same dosage was responsible for an approximate increase of 10% in both luteinizing hormone (otherwise known as LH) and follicle-stimulating hormone (otherwise known as FSH). These increases have been instrumental in linking the catalog chemical to the hypothesized treatment of male-pattern baldness.

It has also been determined that in the case of animal test subjects that have hyperplasia, Finasteride does not exhibit a negative effect on circulating levels of prolactin, thyroxine, cortisol, or thyroid-stimulating hormone. Furthermore, there was no clinically meaningful effect determined on the animal test subject’s bone mineral density or its plasma lipid profile, which would include metrics determining total cholesterol, high density lipoproteins, low density lipoproteins, and triglycerides.

Other Properties of Finasteride

It has been determined through scientific study of animal test subjects that the mean bioavailablity of Finasteride is 63%. Furthermore, maximum finasteride plasma concentration averaged 37ng/mL, and this peak concentration was reached 1 to 2 hours after its introduction. It was also determined that the catalog chemical’s biovailability was not adversely affected by food.

It was also determined that about 90% of catalog chemical upon circulation is bound to plasma proteins, and these particular concentrations do build up over time. The catalog chemical has also been shown to cross the blood brain barrier, but it has been determined that it does not exhibit a preferential distribution to the CSF, or cerebrospinal fluid.

Finasteride’s mean half-life has been determined to be 6.2 hours. However, it has also been determined that this particular number increases in direct proportion to the age of the animal test subject.

And it has also been determined via scientific study based on animal test subjects that Finasteride is metabolized by the liver on an extensive basis. Specifically, it has been shown to be metabolized through the cytochrome P450 3A4 enzyme subfamily.

Click here to read Finasteride Part 1

Click here to view / download PDF

Scammers: South African Extreme Peptides Is A Fraud – Not Legit!

south african extreme peptides

Do not buy from www.extremepeptides.co.za – you will get ripped off!

It has been brought to our attention that there is a rouge Extreme Peptide site operating out of South Africa.

Upon visiting the site it should be obvious that this site is NOT affiliated with us.

  • The site design is absolutely terrible, they did a poor job at mocking our brand.
  • The product selection they offer does not line up to our huge selection of peptides and research chemicals.
  • They only accept bank wires. This alone should be a huge red flag.
  • It has been reported to us that they are not shipping orders that they are receiving payment for.

Not only is the “Extreme Peptides South Africa” site not an authorized retailer of our peptides, they are also ripping off our loyal customer base.

We hope that you find this post before you find that site if you are looking to buy peptides in South Africa.

The real Extreme Peptide site (this one) ships to South Africa. If you need peptides or research chemicals and you live in that region, please visit our homepage and buy your peptides from the proper source.

We are taking the proper action to have the site removed (if possible) through legal channels.

The Real Extreme Peptide
The Real Extreme Peptide

 

Finasteride Part 1

finasteride
Click the image above to view Finasteride in our store

The catalog chemical Finasteride, which is sometimes known as Proscar, Propecia, or MK-906, is a type of type II 5α-reductase inhibitor, which means that it has antiandrogen effects.  In other words, the catalog chemical has been determined that blocks androgens from expressing their biological effects on responsive tissues.  Its molecular formula is C23H36N2O2, and it has a molecular weight of 372.549.  It is considered to be lipophilic in nature, meaning that it has the capacity to dissolve in fats, oils, lipids, and other non-polar solvents.

Operational Mechanics of Finasteride

According to scientific study based on animal test subjects, it has been determined that Finasteride has been shown to be an inhibitor of a specific type of isoenzyme.  What this means is, it inhibits an enzyme that serves as a variant from a normal amino acid sequence, but it nonetheless catalyzes the same type of chemical reaction.  In the case of Finasteride, it has been shown that the presence of the catalog chemical serves to inhibit the expression of 5α-reductase.  This process causes a prevention of the conversion of testosterone into DHT, which is sometimes known by its formal name of dihydoestosterone.  DHT has been shown to be responsible for controlling and regulating the development, growth, and changes associated with specific functions as they relate to the male animal test subject.

These functions typically involve the following:

  • Adrenal glands
  • Prostate glands
  • Testes
  • Hair follicles

Scientific study based on animal test subjects has indicated that the presence of Finasteride does lower the levels of DHT.  However, it does not completely suppress the production of the enzyme entirely.  The reason for this partial reduction is due to the fact that while the catalog chemical does show inhibitory effects on the type II 5α-reductase isoenzyme, it does not show significant inhibitory effects on the type I 5α-reductase isoenzyme.  Studies have determined that the catalog chemical possesses an affinity for the type I version that is 100-fold less than the affinity that it has for the type II version.

Bcause Finasteride possesses the capacity to inhibit the production of DHT, scientific study based on animal test subjects has determined that the catalog chemical’s presence causes a reduction of androgen activity within the scalp.  Furthermore, it has been determined to cause a lowering of the volume of the prostate gland in male animal test subjects.  Additionally, it has been shown to reduce the weight of the epididymis in addition to reducing the motility and normal morphology of the spermatozoa in the epididymis.

Finasteride and Theorized Benefits

Because of the nature of Finasteride and the way it has been shown to inhibit the production of DHT, scientific study based on animal test subjects has determined that the catalog chemical’s presence could play a vital role in providing aid to a host of issues that are related to the enzyme’s production.

For example, it has been determined that the presence of Finasteride could help treat benign prostatic hyperplasia, the condition that is informally referred to as an enlarged prostate.  Because it has been shown to lower prostate volume in male animal test subjects, it is thought that the presence of the catalog chemical could be vital in slowing down prostate enlargement.  This could in turn make the catalog chemical useful in slowing down a wide range of issues relating to the urinary tract, such as hesitation at the start of the urination process, difficulty urinating, and the decrease in urinary flow.

It has also been theorized that Finasteride’s presence could play a vital role in the treatment of hair loss.  Because the catalog chemical has been shown to reduce androgen activity in the scalp, it is hypothesized that the reduction would slow down the process that is responsible for causing hair follicles to stop functioning properly.

Click here to read Finasteride Part 2

Click here to view / download PDF