Anastrozole – Chemical Mechanisms And Study

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Anastrozole is commonly produced under the name Arimidex. This chemical is not naturally occurring and is currently not available outside of laboratory settings. Scientists are currently investigating this chemical’s impact on estrogen receptors or conversion mechanisms– both in an artificial and natural state.

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Anastrozole was designed to act as an aromatase-inhibiting chemical that may have applications toward metastasis. Potential use in combatting the effects of hyperplasia is currently being studied, as is the reactions of anastrozole when interacting with the synthesis of estrogen.

The patent on this chemical expired in 2010 which has opened the door for additional testing and research on these effects.

Chemical Mechanisms

Anastrozole is prepared in laboratory environments by subjecting mesitylene to a radical brominisation process.

  • Anastrozole is prepared by substituting two benzylic for cyanide, treating the chemical with potassium cyanide using a phase transfer condition.
  • The methylation of this chemical with sodium hydridie and methyl iodide creates an acidic compound that includes several methyl groups and hydrogen atoms.
  • Treating bromine along with benzyl peroxide will create a corresponding benzyl bromide reaction that creates the base for the aromatase inhibitor.

Additional compounds can be created using a similar process. This allows manufacturers to create variations on the compound to increase or decrease the strength of the chemical as necessary. Varying compositions of anastrozole can be used in laboratory settings to act as carriers or diluents based on the nature of the study.


Studies are ongoing to determine the usefulness of using anastrozole for medical application in the future.

Ongoing studies are in progress to assist in determining the inhibiting properties of anastrozole as well as the process of compounding these chemicals to create a variation of strengths of this chemical.

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Extreme Peptide launches custom protein expression!

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custom protein

Extreme Peptide has been meeting the needs of clients since 2011. The foundation of our company has been the ability to offer a high quality product, to exact specifications and in a manner that ensures the highest accuracy for your research.  We have compiled a catalog of many standard research proteins and peptides; and we’re adding more every week. All products are available from our website.  Start with the appropriate category (proteins, epidermal growth factors, insulin growth factors, etc.), and search from there.

Is your project more complex? Do you require a high level of confidentiality? Does your organization require proteins expressed and scaled to exact specifications with documentation outlining exact processes and conditions? 

Through our strategic partnerships with some of the world’s leading peptide and chemical manufacturers we are able to offer you viable cost effective solutions to ensure the success of your projects


    1) Protein expression through proprietary software which provide us with the optimal sequence to meet your needs.

    2) An array of purification techniques to meet and exceed your purity requirements.

    3) HPLC,MS,SDS-page and Certificates of analysis are provided upon delivery. 

    4) Flexible and scalable solutions to satisfy your requirements without draining your budget.

    5) Purified proteins free of endotoxins and ready to use in your assays. 

    6) A reasonable production time with a very high level of success.

    7) An understanding and knowledgeable staff who will work hard to meet your needs.


A partnership with Extreme Peptide ensures that you have a professional support team capable of understanding your requirements and delivering custom solutions on specification, on time, and on budget. If you are interested in our protein expression or peptide synthesis services please contact us so that we can discuss your specific needs. We appreciate your interest in our products and services, and we look forward to a long and successful relationship.

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Bremelanotide PT-141 Study – Potential Use

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Bremelanotide is a compound that is currently under investigation for its potential uses in managing reperfusion injury, female sexual dysfunction or hemorrhagic shock. The chemical may also see success in managing modulate inflammation or limiting the effects of ischemia.

Study – Potential Use Erectile Dysfunction

One study has explored the potential use of bremelanotide as a replacement for natural peptide melanocyte stimulating hormones for the sake of treating erectile dysfunction.

  • The goal of this study was to determine if the effects of bremelanotide stimulating sexual desire that was shown in male rats could be replicated in the brains of female rats. To do this, hormone primed female rats in a control group and a test group that were treated with bremelanotide and known to have consummatory sexual disorders was introduced to a group of male rats and the reactions were measured.
  • Heart racing, hops and darts, pacing and customary sexual behaviors were assessed while the brain was stimulated. The stimulation of specific molecular markers within the brain was examined to determine arousal in the female subjects.
  • Results indicated that the females saw an increase in sexual behavior when bremelanotide was applied to the limbic and hypothalamic regions of their brains. It is suggested that this was because the chemical that stimulated the mPOA terminals, leading to activated dopamine in the brain.

Additional study is necessary to determine the extent of the effects bremelanotide has on the brain and natural stimulating chemicals. Research companies buy bremelanodtide in our online store located right here at

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