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Hexarelin refers to the peptide GH secretagogue which is quite similar in structure to GHRP-6. Because hexarelin is synthetic, its effects are not as potent as the naturalized chemicals.

Using hexarelin to stimulate some hormones will cause an insulin-like growth factor or IGF-1 which is the natural substance used to encourage muscle growth in animals. Unlike similar chemicals, hexarelin does not have any impact on appetite or increase of ghrelin levels.

Effects on Subjects of Varying Ages

Hexarelin has been established as an effective chemical in inducing hormone secretions in small mammals, but the effects and stability of this chemical compared to other common options are largely unknown.

• To better understand the effects of hexarelin and how they compared to those of common GH stimulators such as GHRP6, GHRP1 or GHRP2, secretions were studied in rats of varying ages and results were compared to the known stable chemical 2-methyl-trp.

• In 10 day old rats Trp was substituted with 2-methyl-trp and a hexapeptide hexarelin to achieve GH secretion. The chemicals were successful in achieving this stimulation.

In trials, hexarelin appeared to be more effective than GHRP6 in eliciting the desired response. This indicates that hexarelin could be used as an effective releasing agent that could act as a tool for both diagnostic and therapeutic work in clinical practice in the future.

Cardio-protective Effects of Hexarelin

As selected GH deficiency has been established as a risk for cardiac dysfuntion, hexarelin was administered to determine its potential use in addressing this risk.

• Non-GH mediated effects of the heart were examined in hypo-physectomized rats. Throughout the study, rats were administered hexarelin for a week.

• Throughout the study, the hexarelin injections prevented the increases of diastolic or left ventricular pressure and also helped to reduce reactivity of the coronary vasculature to angiotensin II and coronary perfusion pressure.

• In addition to these findings, hexaralin was determined to prevent prostacyclin release levels falling while recovering contractility. Administering natural GH allowed for similar results. However, the administration of EP 51389, was not effective in relieving symptoms.

These conclusions indicate that hexarelin can help to reduce the damage to the cardiovascular system that occurs following ischemia-reperfusion which is not mediated by GH but the activating of certain cardiac receptors. Additional study may reveal a solution of hexarelin that may be administered as a form of preventative care for these circumstances.

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Ongoing study continues to reveal potential uses of hexarelin in mammalian test subjects. This research hopes to address safety issues including proper levels of administration and likely side effects of interaction with this chemical.

Sources:

http://www.sciencedirect.com/science/article/pii/0024320594005109

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Obesity can interfere with the function of organs such as the pituitary gland or pancreas. If these organs cannot receive the proper messages then the system will fail to produce proper levels of chemicals, such as insulin.

Studies are undergoing to determine the effectiveness of using artificial hormones to help regulate these hormone levels. The growth chemical GHRP6 is currently being studied for such a purpose, though it will take some time before any coherent results are determined.

Natural Interactions with Insulin

Natural hormones are designed to stimulate a variety of chemicals to encourage the tissue cells to multiply.

• Hormones are designed to stimulate the pituitary or other glands or what’s secreted from these glands to stimulate tissue. GHRP6 is a chemical that has been designed to mimic the properties of the latter group.

• Different types of hormones are intended to stimulate different types of tissue. This may include stimulating bone knitting or muscle production.

• Some natural hormones will also stimulate the pancreas. If these hormones are not functioning properly it can result in excessive growth that may result in obesity.

It is important to note that artificial hormones such as GHRP6 do not function in the same manner as the natural hormones they are designed to mimic.

In tests on rats it has been shown that chemicals such as GHRP6 remain in the system much longer than hormones which naturally occur in the system. The impact this added time in the system has on the tissues is not yet known.

Impact of GHRP6 on Hypopituitary and Obese Conditions

Scientists have determined that a low reproducibility rate of hormones may increase the risk of obesity.

• To determine the full effects of these hormones, a variety of mice subjects including males and females were studied. Groups included those that were obese, obese but otherwise healthy, those that suffered from hypopituitarism and those with a normal body-mass and health rates. These subjects were checked using a radioimmunoassay to determine the natural hormone rates in their system.

• The study concluded that those mice suffering from hypo-pituitarism, specifically those that were already obese, saw a significant dip in their natural hormones. Those that did not suffer from hypopituitarism or those with a normal body mass index did not see this response.

GHRP6 and acipimox were offered as a potential treatment option to correct these levels in the mice that saw a hormone decrease.

The conclusions showed that doses of acipimox or GHRP6 were not effective in restoring the natural hormone levels necessary to overcome hypopituitarism. However, a combination of the natural GHRH and GHRP6 saw fewer side effects than the other doses.

Additional research will be necessary to determine the safety or full effectiveness of artificial hormones in treating organic conditions.

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Ongoing trials of melanotan II are attempting to discover a way to activate natural melanin in an animal to protect the skin from UV rays that can cause skin cancer by stimulating the natural hormones that cause tanned skin. While research has developed a version of this chemical that is more stable, the trials have not revealed a version of this chemical that has been determined safe for use.

Effects on Sexual Behaviors in Female Rats

The effects of melanotan II were examined to determine their ability to stimulate hormones associated with female sexual behavior on the consummatory and appetitive aspects of the behavior in female rats.

Perceptive behaviors such as ear wiggling, hops and darts, pacing and solicitations, as well as receptive behaviors including lordosis, were measured to determine the effectiveness of the chemical.

One group of female rats was given a subcutaneous primer of estradiol benzonate and progesterone. Another group was primed with EB and oil.

Pacing tests were performed in the company of experienced male rats with uni-level chambers. They were bisected by Plexiglas dividers that had three holes where the female could pass.

Females were primed with EB and oil or melanotan II in three administrations and all sexual behaviors after the administration were measured.

The findings of this study indicate that progesterone can interact with melanotan II to increase sexual behaviors. The behaviors of the rats could indicate solicitations, suggesting that the melanocortin receptors can affect female animals with hypoactive sexual desire.

Reductions of Melanocortin 3 and 4 Receptor Expressions

This experiment hopes to track the effects of chronic activation of central melanocortin with melanotan II in obese rats fed a high fat chow diet.

The rats were given six infusions of melanotan II a day which was found to reduce the visceral adiposity and body weight of the animals compared to those that had a suppressed caloric intake.

The reaction to melanotan II was found to be similar to those exposed to CH or DIO. The rats exposed to melanotan II saw a sustained increase in oxygen consumption similar to that of DIO, but those exposed to CH saw a delayed response.

The melanotan II groups saw a reduction in their cholesterol levels compared to those in the control group.

Results also showed that the melanotan II group saw an increase in catabolism of fat and muscle content. The DIO rats saw an improvement in cholesterol metabolism or glucose rates compared to the other groups.

Ongoing trials are being conducted to better determine a concentration of melanotan II that is safe for use in animal studies without the high risk of hazardous effects.

You can buy peptides and research chemicals in our store, we also have further research on Clomiphene Citrate that may interest you as well.

Sources:

http://www.sciencedirect.com/science/article/pii/S009130570600325X

http://joe.endocrinology-journals.org/content/182/1/123.short

http://strongpeptide.com/blog/melanotan-2

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